It has been shown that 19 of 21 individuals with Klippel-Trenaunay syndrome (KTS), 5 of 8 with fibro-adipose vascular anomaly (FAVA), and 31 of 33 with congenital lipomatous overgrowth with vascular, epidermal and skeletal anomalies (CLOVES) were mosaic for specific PIK3CA mutations [7]. The gene discussed is PIK3CA; the disease is angioosteohypertrophic syndrome.