Furthermore, stably rHK2 (T473A) MCF-7 cells also had decreased resistance to paclitaxel compared with rHK2 (WT or T473D) MCF-7 cells, which suggested phosphorylation of HK2 at T473 played a crucial role in the resistance of breast cancer cells (Fig. 7f). The gene discussed is HK2; the disease is breast carcinoma.