Among these genes, a recently developed mutation significance method (MutSigCV), which provides a statistical metric to identify driver candidates in cancer with respect to the gene nucleotide length and the background mutation rate of each cancer analyzed10, recognized only FAT1 to be significantly mutated when conducting a pancancer analysis (Supplementary Fig. 1a and b, and see below, Fig. 1a). The gene discussed is FAT1; the disease is cancer.