YAP1 and malignant mesothelioma: Indeed, there are only a few examples of known YAP1 regulating genes altered in cancer, which include LATS2 and an upstream Hippo pathway component, NF2, in malignant mesothelioma (35% and 50%, respectively)7, and inherited NF2 mutations and microdeletions in neurofibromatosis type 28, overall accounting for a small fraction of human malignancies displaying YAP1 hyperactivity.