Remarkably, the use of our recently developed REVEALER16 computational approach identified FAT1 truncating mutations as the top genomic abnormality complementary of YAP1 gene amplification significantly associated with YAP1 activity (p = 0.01), as measured by CTGF and CYR61 overexpression, out of a total of 1589 candidate genomic abnormalities in the large cohort (n = 504) of HNSCC (Fig. 1d). Here, CCN2 is linked to head and neck squamous cell carcinoma.