As shown in Fig. 4j and Supplementary Fig. 6i and 7d, two independent YAP1 shRNAs completely abrogated tumor growth in CAL33 and CAL27 cell lines, and strongly inhibited tumor growth of HN12 HNSCC cells, which correlated with decreased proliferation as depicted by BrdU incorporation (Fig. 4k, l, Supplementary Fig. 6j), and in some cells (CAL33), increased expression of the epithelial differentiation marker Cytokeratin 10 (CK10) (Fig. 4k, l). This evidence concerns the gene KRT10 and head and neck squamous cell carcinoma.