Knockdown of YAP1 resulted in significantly smaller spheroid growth in these HNSCC cells (Fig. 4g, and Supplementary Fig. 8b), reduced GAL4-TEAD reporter expression (Fig. 4h and Supplementary Fig. 6g and 7c) and 3–5-fold increase in basal apoptosis (Fig. 4i and Supplementary 6h). This evidence concerns the gene LGALS4 and head and neck squamous cell carcinoma.