Histological analyses by Masson’s trichrome and Picrosirius red staining revealed extensive collagen deposition and scarring in Lyve1–/– hearts on day 21 after MI compared with controls (Picrosirius signal/area ratio quantification: control, 2.28 × 10–10 ± 1.79 × 10–11; Lyve1–/–, 5.22 × 10–10 ± 6.99 × 10–11; P ≤ 0.05; Figure 7, H–N). This evidence concerns the gene LYVE1 and myocardial infarction.