We previously demonstrated that ROCK inhibition with Fasudil improved response to standard-of-care chemotherapy and reduced metastasis of pancreatic cancer cells using intrasplenic and orthotopic models and have shown that Src is a key regulator of metastasis in PC (Erami et al., 2016; Evans et al., 2012; Nobis et al., 2013; Vennin et al., 2017). The gene discussed is SRC; the disease is familial pancreatic carcinoma.