Nuclear cIAP1 overexpression is associated with poor prognosis in bladder cancer, lymph node metastasis and head and neck squamous cell carcinoma patients.47, 48 We found that nuclear cIAP1 expression is much higher in MB cells relative to normal brain tissues, and inversely correlates nuclear p21 expression (Figure 7). The gene discussed is BIRC2; the disease is head and neck squamous cell carcinoma.