Our study showed that TERT promoter mutations (66.42%) occur in many primary GBMs, and the frequency at which these were detected was in line with previous studies (58%‐75%).21, 22 TERT promoter mutations are frequency associated with malignant tumor progression and a capacity for enhanced cell proliferation.23 The unenhanced region on MRI, which represents pathological necrosis, reflects tumor progression. This evidence concerns the gene TERT and neoplasm.