2014), comparable to the levels shown in Figure 1A. (Note: The correct unit of blood urea nitrogen in Table 1 of reference (Hsueh et al. 2014) is probably mg/mL, not mg/L). In apparent conflict with our findings, Hsueh et al. (2014) find a marked ventricular hypertrophy of the hearts in rats with samcystin defect, although heart rate and cardiac pump function (e.g., ejection fraction) are comparable, as in our data. Cardiac hypertrophy has also been reported in another rat model of CKD due to partial nephrectomy (Donohoe et al. 2000a). Here, ANKS6 is linked to Ventricular hypertrophy.