PRRT2 and epilepsy: PRRT2 mutations are known to cause epilepsy, and on a neuronal level, to interfere with glutamatergic signalling, thus resulting in neuronal hyperexcitability.15 Similarly, recent studies also substantiated evidence of pathological glutamatergic neurotransmission underlying Tourette's syndrome.16 Furthermore, there is some evidence suggesting changes in connectivity of certain circuits (cortico‐striato‐pallido‐thalamo‐cortical in tics; thalamomotor‐cortical circuits in PKD with or without PRRT2 mutations) as shared pathophysiological mechanism.17, 18