The mechanisms by which drugs may trigger lupus erythematosus are not well understood, but it has been suggested that certain drugs induce the production of the cytokines TNF-α and IFN-α which have the potential to stimulate and to increase the autoreactive capacity of B and T lymphocytes, or alternatively, some drugs by promoting epigenetic modifications can dysregulate T lymphocyte gene expression, resulting in the T cells becoming autoreactive [27, 28]. Here, TNF is linked to lupus erythematosus.