MTOR and urinary bladder cancer: The extract has also been shown to attenuate aging in C. elegans, D. melanogaster, and S. cerevisiae. In the case of D. melanogaster, the extract increased lifespan up to 24% through a mechanism independent of dietary restriction, a well-established intervention to increase lifespan and healthspan of various organisms [15, 16]. Rhodiola rosea and its putative active compound, salidroside, has been shown to inhibit the mTOR pathway and induce autophagy in bladder cancer cell lines [17].