Ichihara et al. used middle cerebral artery occlusion in mice and oxygen-glucose deprivation in rat cortical neurons to define the role of AhR in stroke, and the results found that L-kynurenine is an endogenous ligand that mediates AhR activation in the brain, and demonstrated that an L-kynurenine/AhR pathway mediates acute brain ischemic damage after stroke[58]. The gene discussed is AHR; the disease is Stroke.