As mentioned above, the detailed mechanisms of antitumor function of FBP1 are still remaining to be unclear; it has elucidated that Snail-G9a-Dnmt1 complex is critical for FBP1 silence, which promoted the interaction of β-catenin and TCF and played an important role in EMT transformation in basal-like breast cancer [25–27]. This evidence concerns the gene HNF4A and breast cancer.