To further explore the underlying roles of FBP expression and methylation of FBP1 promoter region in NSCLC, we first used specific small interfering RNA (siRNA) to downregulate the endogenous level of FBP1 expression in H460 cells that express higher level of FBP1 (Figure 2) and tested the consequences of knocking down of FBP1 expression on cell cycling. Here, FBP1 is linked to non-small cell lung carcinoma.