Thus GHRH(1-29)NH2 at 10 nM-1000 nM concentration reduced the mRNA for IGF-1 in J82, HT-1197, and HT-1376 bladder cancer cells by 28.3±9.5% (p > 0.05), 42.0±2.3% (p < 0.01), and 19.0±4.2% (p < 0.01), respectively; in CFPAC-1 and PANC-1 pancreatic cancer cells by 25.3±5.2% (p < 0.05) and 13.5±10.5% (p > 0.05), respectively; and in MCF7 breast cancer cells by 27.6±5.0% (p < 0.01). The gene discussed is GHRH; the disease is familial pancreatic carcinoma.