Nevertheless, the observations that the GHRH(1-29)NH2 and GHRH agonist, MR-409, inhibited the expression of mRNA for IGF-1 as well as IGF-1 secretion by human and rat hepatocytes and human cancer cells in vitro, after stimulation with rhGH, imply that GHRH agonists may exert these effects by direct action on the cells. Here, GHRH is linked to cancer.