AKT1 and non-small cell lung carcinoma: As the combination of RO3280 and rhTRAIL can synergistically reduce cell viability and induce apoptosis in NSCLC cells, we sought to further investigate additional relevant signaling pathways, such as the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK), the Akt and, the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, which play an essential role in the survival of NSCLC [34].