S100P and colitis: Based on their relative positions noted by enrichment for H3K27ac, confirmed by enrichment in the RNA-seq, and potentially influencing colitis, we chose the triad of LYZ, S100P, and NPSR1. We also compared levels of these three proteins, predicted by the interface of H3K27ac enrichment and RNA-sequencing, in CAC, a devastating sequela of UC, and for which the pathogenesis also remains unclear.