Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch Syndrome is the most frequent hereditary colorectal cancer syndromes and is the result of the presence of germline mutations in MMR genes, mainly MLH1 and MSH2 with somatic inactivation of the remaining wild-type allele [10, 17]. Here, MLH1 is linked to hereditary nonpolyposis colon cancer.