Most likely, these tight microvilli-like interdigitations rendering a zipper-like appearance to the plasma membrane correspond to the NHERF1 membranous staining, and the grape-like intracytoplasmic structures rather than true microlumens, to the NHERF1 dot-like pattern, in high-grade meningiomas with sheeting, clear cell, papillary or rhabdoid change. This evidence concerns the gene NHERF1 and meningioma.