In conclusion, our analysis of NHERF1 expression in meningioma uncovered (1) previously unknown elements of epithelial differentiation in chordoid meningioma that allow the differential diagnosis with other architecturally similar neoplasms and (2) an additional subset of high grade meningiomas with epithelial differentiation and sheeting, clear cell, rhabdoid and papillary-like morphology. Here, NHERF1 is linked to meningioma.