In our study, we have used additional experimental strategies, including time resolved CRISPR depletion assays, analog sensitive kinase mutants, CRISPR screens in MTAP isogenic cell lines and bioinformatics analysis of large scale CRISPR screens, to interrogate the proposed increased sensitivity of MTAP deleted cancer cells on the function of PRMT5, MAT2A and RIOK1. Here, RIOK1 is linked to cancer.