AR and pachyonychia congenita: Mechanistically, the interaction between WNT signaling and AR signaling differs based on PC stage: WNT/ β-catenin signaling is associated with AR-target gene transcription in hormone naïve PC cells; however, in castrate-resistant PC, both AR and WNT/ β-catenin signaling stimulate each other resulting in activation of genes involved in PC cell growth in an androgen-independent manner [39].