Increasing evidence also suggests the involvement of noncanonical NF-kB signaling in cancer pathogenesis, as many of the activating receptors of this pathway, such as the lymphotoxin-beta receptor (LTβR) and cluster of differentiation (CD) 40, are present in the tumor microenvironment and have been implicated in processes such as tumorigenesis [19–21]. The gene discussed is NFKB1; the disease is neoplasm.