TNF and systemic inflammatory response syndrome: Our data also shows that cytokine (TNFα and IL-6), NO, and H2O2 release in the peritoneum is exacerbated in SIRS TRPC5−/− mice pretreated with Trx whilst ML204 partially reversed the inhibitory effects of this protein on IL-6 and IL-10 production, without affecting NO and H2O2 levels.