Moreover, other reports showed that the expression of miRNAs including miR-330-5p, mir-138, and miR-424(322) regulates the expression of TIM-3, CTLA-4, and PD-1/PD-L1 in AML [52], Glioma [54], and ovarian carcinomas [55], respectively. Here, CD274 is linked to central nervous system cancer.