To investigate whether frequencies of caspase-3+IFN-γ+CD4+ T cells in treatment-naive ATB patients are altered following anti-TB treatment, we compared treatment-naïve ATB patients with those who successfully completed 6 months of anti-TB treatment (n = 8) by assessing frequencies of caspase-3+IFN-γ+CD4+ T cells in PBMCs stimulated with Mtb-CW and ESAT6-CFP10. This evidence concerns the gene CASP3 and tuberculosis.