This increased proportion of cases in young women is important because the diagnosis and behavior are generally more aggressive, with a disproportionately greater number of years lost due to cancer 19,20 This is a result of detection at advanced stages, a greater proportion of triple negative tumors with HER2 over-expression and higher rates of systemic relapse in any clinical stage in comparison with postmenopausal women 21-.23 This evidence concerns the gene ERBB2 and cancer.