The control group demonstrated higher expression of CD31 (3.4 vs 1.8), VEGFR2 (2.5 vs 1.2), Ki67 (13.4 vs 10.5), and NG2 (49 vs 41) in the tumor periphery than in the center, whereas cell density (ie, % area of cells) was not spatially different on hematoxylin and eosin staining. The gene discussed is MKI67; the disease is neoplasm.