Western blotting analysis displayed that the expression of the phosphorylation level of p38 and AMPKα in MCF7‐Nanog cells was significantly higher than that in MCF7‐Ctrl cells (Fig. S6), which could explain why MCF7‐Nanog cells were more sensitive to Sme and account for the preferential antitumor activity of Sme against cancer stem‐like cells. The gene discussed is NANOG; the disease is cancer.