It has been reported that radioresistant glioblastoma stem cells acquired enhanced AMPK activity and in normal human mammary epithelial cells AMPK mediated the mammosphere formation, indicating that AMPK might involve in regulating the self‐renewal and therapeutic resistance of CSCs.38, 39 Our study showed that Sme induced apoptosis via activating the p38 MAPK and AMPKα pathways in MCF7‐Nanog cells. Here, NANOG is linked to glioblastoma.