Given that both SOD1 and TDP-43 are associated with motor neuron degeneration in patients with ALS, we aimed to determine if mutant SOD1 expression directly causes biochemical alterations of TDP-43 related to motor neuron degeneration in a NSC34 cell line transiently transfected with mutant SOD1. Here, TARDBP is linked to amyotrophic lateral sclerosis.