Other targets, such as PTEN, p300, and FOXO3a, counteract AKT pro-survival signaling; their derepression observed in AD neurons and probably caused by miR-132 downregulation may induce expression of the key apoptotic effectors Bim and Puma, leading to activation of caspases and apoptotic signaling [67], and also promoting Tau cleavage. Here, EP300 is linked to Alzheimer disease.