Alzheimer’s disease (AD) is a progressive neurodegenerative disorder typified by profound synaptic loss, brain atrophy, and the presence of extracellular plaques composed of amyloid β-protein (Aβ), and intracellular neurofibrillary tangles (NFTs) formed by hyperphosphorylated Tau [3, 27]. The gene discussed is MAPT; the disease is Alzheimer disease.