When subsetting the statistical tests by MAF range, BTH uncovers six associations, including a locus regulating variance of the gene DIS3L, recently identified as a possible risk factor for myocardial infarction (Lee et al., 2017), and a locus regulating the variance of the gene MAP2K1, involved in cardiac signaling (Krysiak et al., 2018; Sheikh et al., 2008) (Supplementary Table S4, Fig. S8). Here, DIS3L is linked to myocardial infarction.