In particular, BTH discovers variance effects of sex in transmembrane protein TMEM14B and in the protein coding genes DC2 (or OSTC), C14orf166 and FRG1. Among these, of interest is the gene C14orf166 which is involved in viral replication in the case of infection with influenza virus A (Rodriguez et al., 2011). This evidence concerns the gene FRG1 and infection.