FMR1 (fragile X mental retardation 1) gene is one of the major genes of interest in this field, as it is associated with premature ovarian insufficiency (POI) and its endpoint premature ovarian failure (POF; OMIM accession number: 615723) and, as its protein FMRP is mainly localized in granulosa cells within the ovary [2, 3]. This evidence concerns the gene FMR1 and primary ovarian failure.