This notion is supported by our immunofluorescent staining observations: (1) the intimate relationship of CuZn‐SOD and nephrin at the cell periphery of the foot process area in control podocytes, and (2) reduction/dislocation of CuZn‐SOD and nephrin expression in shed podocytes from preeclampsia and in control podocytes exposed to hypoxic or oxidative stress conditions. This evidence concerns the gene NPHS1 and preeclampsia.