Glycoproteins including nephrin, podocalyxin, podoplanin, and glomerular epithelial protein 1 (GLEEP‐1) are extensively expressed in the slit diaphragm and/or on the cell surface of podocytes, whereas significant reduction of these glycoproteins is closely associated with increased proteinuria in preeclampsia. The gene discussed is PDPN; the disease is preeclampsia.