showed no significant difference in paraoxonase 1 activity between DM and non‐DM in different population.9, 10, 11, 12, 13, 14 Meanwhile, Mackness et al15 firstly described that paraoxonase 1 activity was significantly higher in DM patients without complications than that with retinopathy in 2000. This evidence concerns the gene PON1 and diabetes mellitus.