PON1 and type 2 diabetes mellitus: Paraoxonase 1, a member of hydrolases with a glycoprotein structure, is a 354 aa glycoprotein of about 45 kD that is synthesized in the liver, released to the blood and binds to the high‐density lipoprotein in calcium‐dependent manner.4 Paraoxonase 1 has been demonstrated approximately 200 nucleotide polymorphisms, such as Q192R polymorphism, which was significantly associated with the susceptibility to T2DM by meta‐analysis.5 Paraoxonase 1 is a multifunctional enzyme with functions of arylesterase, paraoxonase and lactonase.