CD8A and psoriasis: Given that one of the hallmarks of highly pro-inflammatory T cells is the capacity to produce multiple different cytokines, we next used SPICE software (National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD) to analyse the poly-functionality of CD3+CD8− T cells in control, carnosol and curcumin treated psoriasis PBMC (Fig. 9F).