As depicted in Fig. 5a, we analyzed UV-induced CPD levels in two model DNA sequences: (1) a highly mutated ETS binding site in the RPL13A (Ribosomal Protein L13A) promoter, since this site is the most frequently mutated ETS motif in the ICGC melanoma dataset (see Supplementary Table 1 and 2); and (2) ETS binding sites in the promoter of the SDHD (Succinate Dehydrogenase Complex Subunit D) gene (Supplementary Fig. 5a), since mutations at these sites have been linked to decreased SDHD expression and poor prognosis in melanoma patients27. Here, SDHD is linked to melanoma.