A previous study demonstrated that HVHF reverses sepsis-related immunoparalysis in a porcine model of pancreatitis and increases the expression of major histocompatibility complex II and CD14 in monocytes, thereby alleviating oxidative stress and improving the phagocytic ability of polymorphonuclear leukocytes, even reducing bacterial translocation and endotoxaemia [33]. The gene discussed is CD14; the disease is pancreatitis.