PNPLA3 and type 2 diabetes mellitus: Underlying metabolic risk factors for the disease progression include old age (> 50 years), sex (male> female), central obesity, insulin resistance (IR), Type 2 diabetes mellitus (T2DM), increased ferritin levels and genetic polymorphisms (patatin-like phospholipase domain-containing 3 (PNPLA3) I148M polymorphism) [6].