CRH and irritable bowel syndrome: HR was significantly higher in HCs receiving a CRH injection than in HCs treated with placebo (CRH, 70.3 ± 11.2 beats/min; placebo, 61.5 ± 9.0 beats/min; P = .021), and in patients with IBS receiving a CRH injection when compared with those treated with placebo (CRH, 70.5 ± 9.2 beats/min; placebo, 61.7 ± 12.6 beats/min; P = .031).