MAPK14 and obesity due to melanocortin 4 receptor deficiency: Using 2 cohorts for visceral fat and subcutaneous fat (sWAT) of adult patients with 80 and 170 samples, respectively, we found that the expression of p38α (Mapk14) in visceral fat and sWAT from individuals with obesity was reduced compared with those without obesity (Fig 1A and 1D).