PECAM1 and splenic hemangioma: The cells of the red pulp sinusoids are bi-phenotypic immunoreactive for vascular (CD31 and Von Willebrand factor) and histiocytic markers (CD68 and lysozyme).[23] The immunoreactivity for CD8 provides additional evidence for the presence of normal subsets of splenic red pulp lining cells.[23] Most splenic hemangiomas are of cavernous or capillary in nature or of varying proportions of both and have immunoreactivity for vascular markers (CD31, Von Willebrand factor, and CD34).