The cells of the red pulp sinusoids are bi-phenotypic immunoreactive for vascular (CD31 and Von Willebrand factor) and histiocytic markers (CD68 and lysozyme).[23] The immunoreactivity for CD8 provides additional evidence for the presence of normal subsets of splenic red pulp lining cells.[23] Most splenic hemangiomas are of cavernous or capillary in nature or of varying proportions of both and have immunoreactivity for vascular markers (CD31, Von Willebrand factor, and CD34). The gene discussed is VWF; the disease is splenic hemangioma.