CRTC3 expression is reported to be associated with the metabolism of saccharide and lipid.[3,4] Meanwhile, soluble CRTC3 polymorphism is related to the pathogenesis of obesity.[5,6] In this study, we aim to investigate the single nucleotide polymorphism (SNP) of CRTC3, rs3862434, and rs11635252 in patients with acute coronary syndrome, and explore its correlation with the urea nitrogen, creatinine, uric acid, total cholesterol (TC), triglyceride (TG), blood glucose, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C). The gene discussed is CRTC3; the disease is obesity due to melanocortin 4 receptor deficiency.