With regard to the age, ENPP1 K121Q showed a significant association with CHD risk (<60: RR = 1.10, 95%CI = 1.01–1.20, P = .03; ≥60: RR = 1.18, 95%CI = 1.03–1.34, P = .01) (Fig. 4F). This evidence concerns the gene ENPP1 and coronary artery disorder.