ENPP1 and coronary artery disorder: With regard to the male percentage, ENPP1 K121Q showed a significant correlation with CHD risk (<65%: RR = 1.13, 95%CI = 1.00–1.28, P = .01; ≥65%: RR = 1.12, 95%CI = 1.03–1.23, P = .05) (Fig. 4E).