A correlation between novel autoantibodies and diagnosis has been demonstrated by Everett et al., in a specific cohort of SS patients with “idiopathic dry eyes.” The immune-mediated damage of lacrimal glands corresponds to anti-SP1, anti-CA6, and anti-PSP high presence in serum and represent markers for early Sjögren's syndrome diagnosis [47] Some authors showed that classical autoantibodies like ANAs, RF, anti-Ro/SSA, and anti La/SSB have a prognostic value for clinical diagnosis [45]. The gene discussed is CALR; the disease is Sjogren syndrome.