A murine genetic model of LDL-cholesterol- (LDL-C-) driven atherosclerosis, based on complete deficiencies of both the LDL-receptor (Ldlr−/−) and key catalytic component of an apolipoprotein B-edisome complex (Apobec1−/−), which converts apoB-100 to apoB-48, has been extensively characterized. This evidence concerns the gene APOB and atherosclerosis.