The above mentioned association of facial dysmorphisms are only described in MMS, especially in genetic syndromes (Guey et al., 2015) like trisomy 21, loss of BRCC3 deubiquitinating enzyme (Miskinyte et al., 2011), Smith-Magenis syndrome (Girirajan et al., 2007), PHACE(S) syndrome (Heyer et al., 2006), Majewski osteodysplastic primordial dwarfism type II (MOPD II) (Kilic et al., 2012), Seckel syndrome (Rahme et al., 2010) and Alagille syndrome (Rocha et al., 2012). This evidence concerns the gene BRCC3 and microcephalic osteodysplastic primordial dwarfism type II.