Among these SNPs, Zhang et al. discovered that the rs5882 variant in CETP was significantly associated with PCV (G allele; P=0.73E−04), but not with AMD (G allele; P=0.297), and suggested the need to find biological clues about the different underlying HDL pathways by separating PCV from AMD so as to explore the pathogenesis of PCV and AMD [33]. The gene discussed is CETP; the disease is age-related macular degeneration.