The cells are responsive to male hormone 5α-dihydrotestosterone, express endogenously both NKX3.1 and AR, and harbors a truncated PTEN at position 340 (403 full length).28,29 As LNCaP clone FGC is both androgen sensitive and progresses toward AR-independent growth, this cell line model is ideally positioned to test a wide range of small molecule inhibitors used in PCa. This evidence concerns the gene PTEN and posterior cortical atrophy.