We observed that in a cohort of 333 primary PCa patients 14-3-3 proteins are amplified or deleted in 12.7% of patient tumors.40 The frequency of this nucleic acid abnormality is similar to the common PTEN (17%) and FOXO1 (14%) deletions in the same dataset (Fig. 5a). Here, FOXO1 is linked to posterior cortical atrophy.