PTK2 and posterior cortical atrophy: For example, Menon et al. knocked down YWHAZ and PTK2 and found that both proliferation and invasion decreased.51 Silva et al. found that another gene on 8q, an AR co-activator NCOA2, is associated with aggressive PCa and has elevated mRNA expression.52 Therefore, it is likely that several genes on 8q are important in PCa progression and may even have cooperative effects.