Intriguingly, 14-3-3 proteins were consistently found in extracellular vehicles of PCa patients with a Gleason grade 8, which lead Panagopoulos and co-workers to postulate that 14-3-3 proteins are associated with disease progression.53 This observation and data presented here support our hypothesis that 14-3-3 proteins are involved in PCa disease progression, possibly via promoting an escape from pharmacological treatment mechanism. This evidence concerns the gene YWHAQ and posterior cortical atrophy.