Focusing on 14-3-3, PTEN, and FOXO1, we performed detailed genetic analysis of 150 advanced PCa samples (metastatic CRPC).41 In this second dataset, 14-3-3 proteins were amplified or deleted in 38.4% of patient samples, while PTEN and FOXO1 were deleted or mutated in 51 and 17% of cases, respectively (Fig. 5b). This evidence concerns the gene PTEN and posterior cortical atrophy.