CXCR1 and type 2 diabetes mellitus: We found that Cc is comparable to or higher performing than a number of established methods to find the dysregulated pathways, such as HotNet28 in capturing “T2D-related” pathways, which are pathways significantly enriched in literature-mined T2D disease genes with experimental evidence from the DISEASES database,16 both on the EGRN and on generic networks (Supplementary Figure 3, see Supplementary Information for details on comparisons with other methods).