In order to assess the downstream effect of Nfatc4, we gathered putative T2D candidate genes regulated by the NFAT family members from GWAS and literature.23 In particular, we selected 13 highly up-regulated and down-regulated transcriptional targets of Nfatc1 and Nfatc2, namely Etv1, Jazf1, Pparg, Vegfa, Arl15, Pex5l, Rbm38, Rbms1, Slc44a3, Spry2, St6gal1, Tcf7l2, and Wfs1, based on a recent report23 that they inhibit the expression of the first four genes while promoting the expression of the latter nine genes. The gene discussed is WFS1; the disease is type 2 diabetes mellitus.