NFATC4 and type 2 diabetes mellitus: To find the connection between the HiCc pathways and T2D-associated genes, we focused on an eQTL SNP (rs79584546) associated with the expression of the gene NFATC4 (q-value = 1.78E-04), which is associated with four HiCc pathways: Wnt signaling, B-cell receptor signaling, MAPK signaling, and T-cell receptor signaling pathways (Fig. 5a).