The mechanistic connection between NFATC4 and TCF7L2 is particularly of interest as TCF7L2 has been established as a major T2D susceptibility gene.23,24 TCF7L2 is also a member of two of our HiCc pathways, namely B-cell receptor signaling and Wnt signaling pathways. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.