T2D is characterized by insufficient insulin secretion from the β-cells of islets in the pancreas.3 We hypothesize that the high control centrality (HiCc) pathways, representing specific gene sets in a T2D-regulatory network in human pancreatic islets, might control other downstream pathways involved in disease manifestation (see Fig. 1). The gene discussed is INS; the disease is type 2 diabetes mellitus.