The cooperation network includes previously validated interactions of MYC, HIF1A, and AR in cancer but also highlights close association of KDM3A with transcriptional networks of factors rather studied in development and tissue differentiation like JUN, CEBPB, MYOD, SREBF1, SP1, MEIS1, ZEB1, or ELK1 (Table 1). The gene discussed is ZEB1; the disease is cancer.