Furthermore, another study, which included 375 hypertensive and 146 normotensive individuals, showed that genetic variation at the Fok1 polymorphism of the vitamin D receptor gene and 25(OH)D levels were associated with plasma renin activity in hypertension, a finding that supports the vitamin D-VDR complex as a renin regulator in humans [64]. This evidence concerns the gene VDR and Hypertension.